Introduction - the problem:Merkel cell carcinoma (MCC) is a rare and agressive skin cancer with a 5-year overall survival of 40%. Patients are first treated with platinum-based chemotherapies but there is no benefit on survival. Immune checkpoint inhibitors were a revolution in MCC treatment however, on long term, 75%...
Subject: Decoding epigenetics - towards a truly personalized medicine
Introduction - the problem:Epigenetics is the study of stable, heritable changes in gene function that do not change the DNA sequence itself. This is achieved by additional modifications that are added to the DNA. So-called epigenetic modifications play an important role as personalizedmarkers...