Wprowadzenie - problem:ColonoAnalysis to oprogramowanie do wspomagania pracy endoskopistów podczas wykonywania badań kolonoskopowych.Sama aplikacja (rozwiązanie informatyczne) ma trzy podstawowe funkcjonalności:1. Analiza obrazu podczas prowadzenia badania kolonoskopowego mająca na celu zaznaczanie zmian podejrzanych2. Kolonoskopia porównawcza; tzn. umożliwienie endoskopiście w trakcie wykonywania kolonoskopii jednoczesneowe oglądanie obrazu tego samego odcinka jelita grubego...
Subject: Decoding epigenetics - towards a truly personalized medicine
Introduction - the problem:Epigenetics is the study of stable, heritable changes in gene function that do not change the DNA sequence itself. This is achieved by additional modifications that are added to the DNA. So-called epigenetic modifications play an important role as personalizedmarkers...
Introduction - the problem:Merkel cell carcinoma (MCC) is a rare and agressive skin cancer with a 5-year overall survival of 40%. Patients are first treated with platinum-based chemotherapies but there is no benefit on survival. Immune checkpoint inhibitors were a revolution in MCC treatment however, on long term, 75%...
Introduction - the problem:There are a number of pressing issues impacting the development of new pharmaceutical products. Many of these issues are exacerbated by the COVID pandemic. Examples of the issues are that only ~3% of citizens ever join a clinical trial, an average of 15% of people leave...